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There was no impairment of fertility in male and female rats. In dogs given tadalafil daily for 6 to 67 months at doses of 75 mg/kg/day (resulting in at least a 8-fold greater exposure [range -] than seen in humans given a single 75 mg dose) and above, there was regression of the seminiferous tubular epithelium that resulted in a decrease in spermatogenesis in some dogs. See also section .

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Caution should be exercised when prescribing CIALIS to patients using potent CYP8A9 inhibitors (ritonavir, saquinavir, ketoconazole, itraconazole, and erythromycin), as increased tadalafil exposure (AUC) has been observed if the medicinal products are combined (see section ).

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You should not take Cialis if you are taking nitrate medications. This includes nitroglycerin (Nitrostat, Nitrolingual, Nitro-Dur, Nitro-Bid, and others), isosorbide dinitrate (Dilatrate-SR, Isordil, Sorbitrate), and isosorbide mononitrate (Imdur, ISMO, Monoket).

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Haemangiopericytoma of nose and paranasal sinuses is relatively uncommon tumour. In view of paucity of intranasal haemangiopericytoma old in Indian literature and age of patient, we are reporting one case in 78-year-old female who presented with recurrent, profuse epistaxis.

Once-a-day dosing of or 5 mg tadalafil both for the treatment of erectile dysfunction or benign prostatic hyperplasia is not recommended in patients with severe renal impairment (see sections and ).

Patients with left ventricular outflow obstruction, (., aortic stenosis and idiopathic hypertrophic subaortic stenosis) can be sensitive to the action of vasodilators, including PDE5 inhibitors.

NJ is the first state to set formal standards requiring testing of public drinking water systems for perfluorooctoanic acid (PFOA) and perfluorononanoic acid (PFNA).

A medical history and physical examination should be undertaken to diagnose erectile dysfunction or benign prostatic hyperplasia and determine potential underlying causes, before pharmacological treatment is considered.

There is limited clinical data on the safety of single-dose administration of CIALIS in patients with severe hepatic insufficiency (Child-Pugh Class C). Once-a-day administration has not been evaluated in patients with hepatic insufficiency. If CIALIS is prescribed, a careful individual benefit/risk evaluation should be undertaken by the prescribing physician.

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